Synthesis of non-aromatics indolizidine alkaloids

Abstract

Indolizidine alkaloids are chemical constituents which can isolated from a variety of terrestrial and marine plants and animals.Indolizidine alkaloids possess 1-azabicyclo [4.3.0] nonane system as the core structure.This alkaloids have been used for a wide range of pharmacology with a various biological activities. It was isolated from plant in families Asclepiadaceae, Convolvulaceae (morning glory), Orchidaceae (orchid), Fabaceae (or Leguminosae) and Pandanaceae. In this research, we will discuss synthetic studies of two members of non-aromatic indolizidine containing alkaloids which are tashiromine, a 5-hydroxymethylindolizidine alkaloid and indolizidine 167B via N-acyliminium ion cyclization as a key step.

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